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SETAC 2022 Review

It was wonderful to see so many of our clients, collaborators and friends at SETAC Europe in Copenhagen last month. For many of us it was the first chance in 2 years to get together in person. We hope you enjoyed it as much as we did!

There was a great spread of interesting scientific topics. One significant scientific advancement we noticed was the proliferation of TKTD modelling talks and posters beyond its usual home in the effects modelling session. This approach is starting to establish itself as a “go to” method for the future – a progression our ecotoxicologist Dr Alice Tagliati contributed too with two posters on the application of the approach in regulatory risk assessment.

The session on the new (draft) updated EFSA birds and mammals guidance document was also particularly interesting, giving insight on the key changes to the effect assessment and presenting discussions from regulators, industry and academia. It is clear that with this update, the risk assessment will become more extensive, with more scenarios relevant to each proposed use. The increased potential to fail lower tier risk assessments thereby requiring greater higher tier refinement was also illustrated, balanced only by the improved guidance on how higher tier (field) studies might be conducted. The guidance will be finalised by the end of 2022, together with a Calculator tool, with final implementation in regulatory risk assessment decided afterwards by risk managers. The precise timing of this last step is as yet, unknown, however once noted, addressing this aspect of the risk assessment may become more challenging for substance approval in the future. Watch this space for news and updates.

Another topical area was the continued discussion on endocrine disruption assessments. Whilst the topic is not new, the recent implementation of the EFSA/ECHA guidance on ED assessments as part of the regulatory process has thrown up a number of challenges. Another of our ecotoxicologists, Dr Charles Hazlerigg, was there presenting on a possible solution for understanding the population relevance of adverse effects on individuals caused by endocrine disruptors. Whilst population and community modelling continue to face hurdles in application in a regulatory context, it is only with relentless efforts such as Charles’ that we may realise their potential. Keep the faith!

Thank you to the session chairs that provided a platform for Enviresearch’s contributions to this great event and thank you to the organisers for putting on an excellent event. We look forward to seeing you all in Dublin next year.

If you would like to hear anything further on our presentations, please contact Alice and Charles directly at This email address is being protected from spambots. You need JavaScript enabled to view it. and This email address is being protected from spambots. You need JavaScript enabled to view it.

Review and Download Charles & Alice's posters here: 

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